Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423960 | 1.00 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9423940 | 0.88 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9423942 | 0.88 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9424120 | 0.73 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9424117 | 0.73 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9424453 | 0.72 | SMN1; SMN2 (0.46) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9424451 | 0.72 | SMN1; SMN2 (0.46) | ALDH1A1GAAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9424021 | 0.71 | POLB (0.41) | ALDH1A1GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9424023 | 0.71 | POLB (0.41) | ALDH1A1GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9424265 | 0.71 | LMNA (0.42) | ALDH1A1SMN1; SMN2KDM4ETSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |