Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424309 | 1.00 | ADRA2C (0.49) | ADRA2CDRD2DRD3NCF1SIGMAR1 | |
| SCHEMBL9059572 | 0.88 | NPC1 (0.44) | SIGMAR1MAPK1MAPTKMT2AKDM4E | |
| SCHEMBL9059574 | 0.88 | NPC1 (0.44) | SIGMAR1MAPK1MAPTKMT2AKDM4E | |
| SCHEMBL9059683 | 0.87 | NPC1 (0.46) | SIGMAR1MAPK1MAPTKDM4EPOLB | |
| SCHEMBL9059681 | 0.87 | NPC1 (0.46) | SIGMAR1MAPK1MAPTKDM4EPOLB | |
| SCHEMBL9059192 | 0.84 | SIGMAR1 (0.40) | SIGMAR1 | |
| SCHEMBL2707104 | 0.84 | SIGMAR1 (0.40) | SIGMAR1MAPTLMNAKMT2AALDH1A1 | |
| SCHEMBL6553147 | 0.84 | SIGMAR1 (0.40) | SIGMAR1MAPTLMNAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9424101 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MAPTLMNAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9424098 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MAPTLMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |