Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424320 | 1.00 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| Iodide SCHEMBL9423861 | 0.99 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| Iodide SCHEMBL9423859 | 0.99 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| Iodide SCHEMBL9423947 | 0.86 | L3MBTL1 (0.50) | KMT2AMEN1L3MBTL1SMN1; SMN2CYP1A2 | |
| Iodide SCHEMBL9423948 | 0.86 | L3MBTL1 (0.50) | KMT2AMEN1L3MBTL1SMN1; SMN2CYP1A2 | |
| SCHEMBL9424125 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| SCHEMBL9424126 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| Iodide SCHEMBL9424035 | 0.85 | SMN1; SMN2 (0.53) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| Iodide SCHEMBL9424032 | 0.85 | SMN1; SMN2 (0.53) | ALDH1A1KMT2AMEN1L3MBTL1RECQL | |
| Iodide SCHEMBL9424038 | 0.83 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |