Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627654 | 0.79 | ALDH1A1 (0.39) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL23426202 | 0.77 | ALDH1A1 (0.39) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL15703279 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL1628153 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL8653747 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL6797157 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL365601 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL11067883 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL1332943 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A | |
| SCHEMBL502191 | 0.73 | TRIM24 (0.43) | ALDH1A1NOS1NOS2NOS3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334712-A | Estrane or androstane pyridinyl alkyl or alkylphenyl amine steroids for antidiabetes and obesity | THE UPJOHN COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| US-5274089-A | A estra-1,3,5(10)-triene derivative | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-5196542-A | Phospholipase A2 inhibitors | THE UPJOHN COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| US-5187299-A | Phospholipase inhibitors; treating diabetes, obesity | THE UPJOHN COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| US-5145874-A | Phospholipase inhibitor, hypoglycemic agent, antidiabetic, obesity | THE UPJOHN COMPANY (US) | 1992-09-08 | — | — | US | disclosed |
| US-4917826-A | TREATING DIABETES AND OBESITY | THE UPJOHN COMPANY (US) | 1990-04-17 | — | — | US | disclosed |