Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 16/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 8/20 | 1.00 |
| ▸ | NQO2 | P16083 | 3/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017220 | 0.87 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL9493664 | 0.84 | MTNR1A (0.81) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL9491217 | 0.84 | MTNR1A (0.81) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL9526273 | 0.82 | MTNR1A (0.82) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| Agomelatine SCHEMBL27844916 | 0.82 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| Agomelatine SCHEMBL1158495 | 0.82 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| Agomelatine SCHEMBL29930659 | 0.82 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| Agomelatine SCHEMBL114476 | 0.82 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL9526855 | 0.81 | MTNR1A (0.79) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| Agomelatine SCHEMBL1289524 | 0.81 | MTNR1A (0.97) | MTNR1AMTNR1BNQO2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318994-A | Treating melatoninergic disorders | ADIR ET COMPAGNIE (FR) | 1994-06-07 | — | — | US | claimed |
| EP-0447285-B1 | NAPHTHALENE DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-05-12 | — | — | EP | claimed |
| EP-0447285-A1 | Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-09-18 | — | — | EP | claimed |
| US-5225442-A | Melatoninergic disorders | ADIR ET COMPAGNIE (FR) | 1993-07-06 | — | — | US | disclosed |
| US-5194614-A | COMPOUNDS HAVING A NAPHTHALENE STRUCTURE | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |