Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548425 | 0.91 | ITGB3 (0.42) | GRM5ITGB3ITGA2BAOC3BCHE | |
| SCHEMBL8547988 | 0.85 | ITGB3 (0.49) | GRM5ITGB3ITGA2BAOC3 | |
| SCHEMBL8590285 | 0.83 | FAAH (0.46) | ITGB3ITGA2BTNIK | |
| SCHEMBL8544909 | 0.81 | ITGB3 (0.54) | GRM5ITGB3ITGA2BAOC3 | |
| SCHEMBL8543052 | 0.78 | ITGB3 (0.51) | GRM5ITGB3ITGA2BAOC3 | |
| SCHEMBL8543749 | 0.76 | ITGB3 (0.51) | GRM5ITGB3ITGA2BAOC3 | |
| SCHEMBL8543334 | 0.76 | ITGB3 (0.48) | GRM5ITGB3ITGA2BAOC3 | |
| SCHEMBL9425527 | 0.76 | ITGB3 (0.49) | GRM5ITGB3ITGA2BTNIKAOC3 | |
| SCHEMBL8543577 | 0.74 | ITGB3 (0.49) | GRM5ITGB3ITGA2BTNIKAOC3 | |
| SCHEMBL29438690 | 0.74 | GRM5 (0.62) | GRM5ITGB3ITGA2BTNIKACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350761-A | Lipoxygenase inhibitors as antiinflammatory agents and antiallergens | CIBA-GEIGY CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| US-5334600-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| US-5260316-A | Lipoxygenase inhibitor | CIBA-GEIGY CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0526402-A1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |