Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.59 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.59 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599554 | 0.83 | PRSS1 (0.71) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL31693012 | 0.78 | F2 (0.65) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL841312 | 0.78 | ITGB3 (0.66) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL1189501 | 0.78 | F2 (0.65) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL13094273 | 0.78 | ITGB3 (0.66) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL13094271 | 0.78 | ITGB3 (0.66) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL1438132 | 0.78 | PRSS1 (0.65) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7890748 | 0.78 | CYP1A1 (0.55) | — | |
| SCHEMBL15058154 | 0.77 | F2 (0.54) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL30314839 | 0.77 | ITGB3 (0.64) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630366-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | G.D. Searle & Co. (US) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993008164-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1993-04-29 | — | — | WO | disclosed |