Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.66 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.66 |
| ▸ | F2 | P00734 | 2/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.65 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.65 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.65 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.65 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.65 |
| ▸ | FURIN | P09958 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30314839 | 0.98 | ITGB3 (0.64) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL13094273 | 0.96 | ITGB3 (0.66) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL3081459 | 0.95 | ITGB3 (0.64) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| Hydrochloric Acid SCHEMBL30701848 | 0.95 | ITGB3 (0.64) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL3093114 | 0.95 | ITGB3 (0.64) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL8693097 | 0.94 | ITGB3 (0.72) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| Hydrochloric Acid SCHEMBL27480576 | 0.92 | ITGB3 (0.70) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL8410379 | 0.89 | ITGB3 (0.67) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL8502841 | 0.88 | ITGB3 (0.68) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL14599554 | 0.87 | PRSS1 (0.71) | ITGB3ITGA2BF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267702-A1 | Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis | HUANG TIEN L | 2010-10-21 | — | — | US | disclosed |
| US-20080279917-A1 | Bisbenzamidines for the Treatment of Pneumonia | XAVIER UNIVERSITY | 2008-11-13 | — | — | US | disclosed |
| US-20080139534-A1 | or sleeping sickness, caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense; lethargy, continous sleep, breakdown of neurological function, coma and death; viricide, antiprotozoa agent; Pentamidine analog; topoisomerases II inhibitor; inhibit synthesis of DNA, RNA by parasites | XAVIER UNIVERSITY OF LOUISIANA (US) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139534-A1 | or sleeping sickness, caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense; lethargy, continous sleep, breakdown of neurological function, coma and death; viricide, antiprotozoa agent; Pentamidine analog; topoisomerases II inhibitor; inhibit synthesis of DNA, RNA by parasites | TOP2A, TOP2B, TOP1 | ITGB3 4818/4885ITGA2B 4471/4885F2 1783/4885 |
| US-20080279917-A1 | Bisbenzamidines for the Treatment of Pneumonia | PBRM1, BHMT, BBOX1 | ITGB3 2882/4885ITGA2B 3356/4885F2 2230/4885 |
| US-20100267702-A1 | Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis | PBRM1, TFB2M, ABAT | ITGB3 2078/4885ITGA2B 1293/4885F2 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.