Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10919540 | 0.80 | KMT2A (0.33) | KMT2AALOX15BLMPMP22MEN1 | |
| Bromide SCHEMBL10918306 | 0.77 | KMT2A (0.33) | KMT2AALOX15BLMPMP22MEN1 | |
| Hydrochloric Acid SCHEMBL9819615 | 0.72 | — | — | |
| SCHEMBL5536956 | 0.70 | ACE2 (0.46) | — | |
| SCHEMBL5531402 | 0.69 | ACE2 (0.49) | — | |
| SCHEMBL5538410 | 0.69 | ACE2 (0.49) | — | |
| SCHEMBL5533797 | 0.69 | ACE2 (0.49) | — | |
| SCHEMBL5535310 | 0.69 | ACE2 (0.49) | — | |
| SCHEMBL5533507 | 0.69 | ACE2 (0.49) | — | |
| SCHEMBL5533237 | 0.69 | ACE2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296483-A | Antidepressant | UNIVERSITY OF FLORIDA (US) | 1994-03-22 | — | — | US | disclosed |
| US-5082853-A | Drug delivery | BODOR NICHOLAS S (US) | 1992-01-21 | — | — | US | disclosed |
| US-4933438-A | Brain-specific analogues of centrally acting amines | UNIVERSITY OF FLORIDA (US) | 1990-06-12 | — | — | US | disclosed |
| EP-0174342-B1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES | UNIVERSITY OF FLORIDA (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4771059-A | CENTRAL NERVOUS SYSTEM | UNIVERSITY OF FLORIDA (US) | 1988-09-13 | — | — | US | disclosed |
| EP-0174342-A1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES. | UNIV FLORIDA (US) | 1986-03-19 | — | — | EP | disclosed |
| WO-1985003937-A1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES | UNIVERSITY OF FLORIDA (US) | 1985-09-12 | — | — | WO | disclosed |