Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963868 | 0.89 | DRD2 (0.63) | DRD2DRD4DRD3CTSSALDH1A1 | |
| SCHEMBL9720664 | 0.87 | DRD2 (0.62) | DRD2DRD4DRD3CTSS | |
| SCHEMBL8963661 | 0.83 | CYP3A4 (0.49) | DRD2DRD4DRD3CTSSMEN1 | |
| SCHEMBL8964019 | 0.82 | DRD2 (0.71) | DRD2DRD4DRD3CTSSALDH1A1 | |
| Hydrochloric Acid SCHEMBL10644520 | 0.81 | DRD2 (0.56) | DRD2DRD4DRD3CTSS | |
| SCHEMBL9720668 | 0.81 | DRD2 (0.55) | DRD2DRD4DRD3CTSSALDH1A1 | |
| SCHEMBL9725056 | 0.80 | DRD4 (0.67) | DRD2DRD4DRD3CTSSLMNA | |
| SCHEMBL8963961 | 0.78 | DRD2 (0.58) | DRD2DRD4DRD3CTSSCYP3A4 | |
| SCHEMBL8964084 | 0.77 | DRD2 (0.52) | DRD2DRD4DRD3CTSSALDH1A1 | |
| Lifarizine SCHEMBL676318 | 0.77 | DRD2 (0.57) | DRD2DRD4DRD3CTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276034-A | Cardiovascular disorders, nervous system disorders, diuretics, antiischemic agents or antispasmodic agents | SYNTEX PHARMACEUTICAL LTD. (GB) | 1994-01-04 | — | — | US | disclosed |