Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.57 |
| ▸ | CTSK | P43235 | 4/20 | 0.57 |
| ▸ | NMT1 | P30419 | 6/20 | 0.49 |
| ▸ | NMT2 | O60551 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9718268 | 0.91 | CTSS (0.60) | CTSSCTSKNMT1NMT2HDAC4 | |
| SCHEMBL9425883 | 0.83 | CTSS (0.45) | CTSSCTSKNMT1NMT2HDAC4 | |
| SCHEMBL1861303 | 0.81 | CTSK (0.69) | CTSSCTSKNMT1NMT2HDAC4 | |
| SCHEMBL1861306 | 0.81 | CTSK (0.69) | CTSSCTSKNMT1NMT2HDAC4 | |
| SCHEMBL506749 | 0.80 | CTSK (0.55) | CTSSCTSKCAPN1TDP1EPHX1 | |
| SCHEMBL21561570 | 0.80 | CTSK (0.55) | CTSSCTSKCAPN1TDP1EPHX1 | |
| SCHEMBL506750 | 0.80 | CTSK (0.55) | CTSSCTSKCAPN1TDP1EPHX1 | |
| SCHEMBL5967594 | 0.78 | CTSS (0.52) | CTSSCTSKCAPN1TDP1 | |
| SCHEMBL12143788 | 0.78 | CTSS (0.52) | CTSSCTSKCAPN1TDP1 | |
| SCHEMBL4073139 | 0.78 | EPHX1 (0.60) | CTSSCTSKKMT2ATDP1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5290799-A | 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0544287-A1 | Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E.R. SQUIBB & SONS, INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |