Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 17/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425967 | 1.00 | BRAF (0.36) | BRAFKCNJ11ABCC9CYP3A4LMNA | |
| SCHEMBL10446808 | 0.81 | KCNJ11 (0.41) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| SCHEMBL9425848 | 0.80 | ABL1 (0.38) | KCNJ11LMNAMEN1POLBKMT2A | |
| SCHEMBL9456838 | 0.79 | ABCC9 (0.51) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| Pinacidil Anhydrous SCHEMBL2131829 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| Naminidil SCHEMBL7639234 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| Pinacidil Anhydrous SCHEMBL2131822 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| Pinacidil Anhydrous SCHEMBL65788 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| Naminidil SCHEMBL1159568 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9CYP3A4LMNACYP1A2 | |
| Naminidil SCHEMBL7639232 | 0.78 | ABCC9 (0.56) | KCNJ11ABCC9CYP3A4LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371086-A | Circulatory disorders side effect reduction | THE GREEN CROSS CORPORATION (JP) | 1994-12-06 | — | — | US | disclosed |
| US-5262415-A | FOR TREATING DISEASES OF THE CIRCULATORY SYSTEM | THE GREEN CROSS CORPORATION (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0503627-A1 | Aminopyridine compounds | THE GREEN CROSS CORPORATION (JP) | 1992-09-16 | — | — | EP | disclosed |