Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.69 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17337999 | 0.96 | GABRA1 (0.68) | GABRA1GABRB2HTTKDM4E | |
| SCHEMBL17337966 | 0.95 | GABRA1 (0.67) | GABRA1GABRB2HTTKDM4E | |
| SCHEMBL4186490 | 0.87 | KDM4E (0.57) | GABRA1GABRB2HTTKDM4E | |
| SCHEMBL396402 | 0.86 | GABRA1 (0.73) | GABRA1GABRB2HTTKDM4E | |
| SCHEMBL17337950 | 0.86 | GABRA1 (0.56) | GABRA1GABRB2HTT | |
| SCHEMBL17337963 | 0.84 | KDM4E (0.56) | GABRA1GABRB2HTTKDM4E | |
| SCHEMBL3812183 | 0.82 | HTT (0.52) | GABRA1GABRB2HTTKDM4E | |
| SCHEMBL17337938 | 0.81 | HTR1A (0.54) | GABRA1GABRB2 | |
| SCHEMBL18589522 | 0.81 | GABRA1 (0.76) | GABRA1GABRB2 | |
| SCHEMBL3812486 | 0.80 | GABRA1 (0.53) | GABRA1GABRB2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154981-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | Université du Droit et de la Santé de Lille 2 (FR) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015189523-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | UNIVERSITE DU DROIT ET DE LA SANTE LILLE 2 (FR) | 2015-12-17 | — | — | WO | disclosed |
| US-5362734-A | Certain benzo-quinolizine compounds and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0494978-A1 | HETEROCYCLIC COMPOUNDS. | WYETH JOHN & BROTHER LTD (GB) | 1992-07-22 | — | — | EP | disclosed |
| WO-1991005783-A1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-05-02 | — | — | WO | disclosed |