Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 8/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | MAX | P61244 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.31 |
| ▸ | MITF | O75030 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427697 | 1.00 | PTGS1 (0.60) | PTGS1PTGS2ALDH1A1MAPTGAA | |
| SCHEMBL9598502 | 0.79 | MYC (0.56) | PTGS1PTGS2ALDH1A1MAPTGAA | |
| SCHEMBL7701811 | 0.75 | PTGS2 (1.00) | PTGS1PTGS2ALDH1A1MAPTGAA | |
| SCHEMBL9427916 | 0.72 | PTGS1 (0.55) | PTGS1PTGS2MAPTGAAPOLB | |
| SCHEMBL9427909 | 0.72 | PTGS1 (0.55) | PTGS1PTGS2MAPTGAAPOLB | |
| SCHEMBL9428429 | 0.70 | PTGS2 (0.56) | PTGS2ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL9476222 | 0.70 | MRE11 (0.47) | PTGS1PTGS2KMT2APOLBMEN1 | |
| SCHEMBL9428425 | 0.70 | PTGS2 (0.56) | PTGS2ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL9427610 | 0.70 | MRE11 (0.47) | PTGS1PTGS2KMT2APOLBMEN1 | |
| SCHEMBL9429104 | 0.69 | NAT1 (0.51) | ALDH1A1MAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270319-A | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | claimed |
| US-5348957-A | Gastrointestinal ulcer treatment | WARNER-LAMBERT COMPANY (US) | 1994-09-20 | — | — | US | disclosed |
| US-5270319-A | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| WO-1993005039-A1 | 5-HYDROXY-2-PYRIMIDINYLMETHYLENE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-18 | — | — | WO | disclosed |