Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | NAT1 | P18440 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427916 | 1.00 | PTGS1 (0.55) | PTGS1PTGS2NAT1AKR1B1HPGD | |
| SCHEMBL9427610 | 0.86 | MRE11 (0.47) | PTGS1PTGS2PIM1POLB | |
| SCHEMBL9476222 | 0.86 | MRE11 (0.47) | PTGS1PTGS2PIM1POLB | |
| SCHEMBL9428429 | 0.86 | PTGS2 (0.56) | PTGS2NAT1CISD1MAOAMAOB | |
| SCHEMBL9428425 | 0.86 | PTGS2 (0.56) | PTGS2NAT1CISD1MAOAMAOB | |
| SCHEMBL9477606 | 0.82 | CSNK2A2 (0.39) | PTGS1PTGS2NAT1AKR1B1HPGD | |
| SCHEMBL15101830 | 0.74 | PIM1 (0.54) | NAT1AKR1B1HPGDGSK3BTDP1 | |
| SCHEMBL9427692 | 0.72 | PTGS1 (0.60) | PTGS1PTGS2HPGDRAB9APOLB | |
| SCHEMBL8962138 | 0.71 | PTGS2 (1.00) | PTGS1PTGS2NAT1AKR1B1HPGD | |
| SCHEMBL3667216 | 0.71 | PTGS2 (1.00) | PTGS1PTGS2NAT1AKR1B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270319-A | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | claimed |
| WO-1993005039-A1 | 5-HYDROXY-2-PYRIMIDINYLMETHYLENE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-18 | — | — | WO | claimed |
| US-5348957-A | Gastrointestinal ulcer treatment | WARNER-LAMBERT COMPANY (US) | 1994-09-20 | — | — | US | disclosed |
| WO-1993005039-A1 | 5-HYDROXY-2-PYRIMIDINYLMETHYLENE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-18 | — | — | WO | disclosed |