Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428008 | 0.85 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9427636 | 0.81 | ALOX5 (0.58) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9428888 | 0.80 | PDE10A (0.45) | MAPTALOX5ALOX5APPDE10A | |
| SCHEMBL9427951 | 0.79 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9428049 | 0.79 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9427782 | 0.78 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9472825 | 0.77 | PPARA (0.46) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| Propionic Acid SCHEMBL9428064 | 0.74 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7544483 | 0.73 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9429907 | 0.73 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364944-A | Antiinflammatory, antiallergic and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-15 | — | — | US | disclosed |
| US-5218124-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |