Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GALK1 | P51570 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428558 | 0.88 | PTGS2 (0.62) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9429816 | 0.86 | NPC1 (0.49) | PTGS2SMN1; SMN2TP53FLT1KDR | |
| SCHEMBL9429587 | 0.86 | PTGS2 (0.56) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL8375473 | 0.86 | PTGS2 (0.65) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9428652 | 0.85 | PTGS2 (0.59) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9429364 | 0.85 | PTGS2 (0.62) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9429179 | 0.84 | PTGS2 (0.65) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9430073 | 0.83 | PTGS2 (0.56) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9429402 | 0.82 | PTGS2 (0.58) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 | |
| SCHEMBL9429382 | 0.81 | PTGS2 (0.55) | PTGS2MEN1KMT2AGALK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |