Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429873 | 0.87 | MAPT (0.47) | PTGS2SMN1; SMN2FLT1KDRTP53 | |
| SCHEMBL9428709 | 0.86 | PTGS2 (0.60) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9430073 | 0.85 | PTGS2 (0.56) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9428558 | 0.85 | PTGS2 (0.62) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9429402 | 0.85 | PTGS2 (0.58) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9429382 | 0.84 | PTGS2 (0.55) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL8375473 | 0.83 | PTGS2 (0.65) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9428652 | 0.82 | PTGS2 (0.59) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9429364 | 0.82 | PTGS2 (0.62) | PTGS2SMN1; SMN2FLT1KDRMEN1 | |
| SCHEMBL9429179 | 0.81 | PTGS2 (0.65) | PTGS2SMN1; SMN2FLT1KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |