Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.67 |
| ▸ | FEN1 | P39748 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.51 |
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772679 | 0.85 | ALDH1A1 (0.84) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL3744237 | 0.83 | ALDH1A1 (0.64) | ERCC5FEN1ALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL10434191 | 0.81 | ALDH1A1 (0.62) | ERCC5FEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL3417241 | 0.81 | ALDH1A1 (0.67) | ERCC5FEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL12867865 | 0.81 | PRKDC (0.51) | ERCC5FEN1ALDH1A1HPGDNQO2 | |
| SCHEMBL242273 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDNQO2KDM4ERPA1 | |
| SCHEMBL14138088 | 0.79 | NQO2 (0.57) | ERCC5FEN1ALDH1A1HPGDNQO2 | |
| SCHEMBL9613179 | 0.79 | ALDH1A1 (0.68) | ERCC5FEN1ALDH1A1HPGDNQO2 | |
| SCHEMBL307282 | 0.77 | ALDH1A1 (0.92) | ERCC5FEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL4896906 | 0.77 | ALDH1A1 (0.66) | ALDH1A1HPGDNQO2KDM4ENR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |