Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | GRK2 | P25098 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644901 | 0.81 | MAPK1 (0.56) | ALDH1A1HPGDMAPK1SLC16A3TSHR | |
| SCHEMBL8868044 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPK1SLC16A3TSHR | |
| SCHEMBL8419387 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPK1SLC16A3TSHR | |
| SCHEMBL10088206 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL8421130 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDMAPK1SLC16A3TSHR | |
| SCHEMBL607963 | 0.80 | MAPK1 (0.54) | ALDH1A1HPGDMAPK1SLC16A3TSHR | |
| SCHEMBL28513100 | 0.78 | MAPK1 (0.49) | ALDH1A1HPGDMAPK1SLC16A3TSHR | |
| SCHEMBL5101721 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL1644885 | 0.77 | MAPK1 (0.59) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL7473218 | 0.77 | SLC16A3 (0.49) | ALDH1A1HPGDMAPK1SLC16A3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |