Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 17/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429030 | 0.97 | OPRM1 (0.46) | OPRM1SIGMAR1HRH1ADRA1DADRA1A | |
| Oxalic Acid SCHEMBL9428762 | 0.86 | HRH1 (0.44) | HRH1ADRA1DADRA1AADRA1BMEN1 | |
| Oxalic Acid SCHEMBL9428727 | 0.84 | HRH1 (0.48) | HRH1ADRA1DADRA1AADRA1BMEN1 | |
| Oxalic Acid SCHEMBL9429467 | 0.83 | HRH1 (0.48) | SIGMAR1HRH1ADRA1DADRA1AADRA1B | |
| Oxalic Acid SCHEMBL9428780 | 0.81 | HRH1 (0.47) | HRH1ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL9428857 | 0.81 | HRH1 (0.48) | HRH1ADRA1DADRA1AADRA1BMEN1 | |
| Oxalic Acid SCHEMBL9383042 | 0.80 | SIGMAR1 (0.53) | SIGMAR1HRH1ADRA1DADRA1AADRA1B | |
| Oxalic Acid SCHEMBL9383037 | 0.80 | SIGMAR1 (0.53) | SIGMAR1HRH1ADRA1DADRA1AADRA1B | |
| Oxalic Acid SCHEMBL9428773 | 0.80 | HRH1 (0.48) | HRH1ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL9429102 | 0.80 | MEN1 (0.44) | HRH1ADRA1DADRA1AADRA1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |