Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Uracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.77 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL479740 | 0.89 | CRBN (0.74) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL4652740 | 0.89 | CRBN (0.74) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL27799965 | 0.88 | CRBN (0.90) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL8235 | 0.88 | — | — | |
| Uracil SCHEMBL5089507 | 0.88 | — | — | |
| Uracil SCHEMBL11607890 | 0.88 | — | — | |
| Uracil SCHEMBL3798527 | 0.88 | CRBN (1.00) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL2895220 | 0.87 | CRBN (0.71) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL28414335 | 0.86 | CRBN (0.77) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL25208560 | 0.86 | CRBN (0.63) | CRBNMMP2TP53ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110462897-A | Positive active material for lithium secondary battery, positive electrode for lithium secondary battery and lithium secondary battery | SUMITOMO CHEMICAL CO | 2019-11-15 | — | — | CN | disclosed |
| CN-110366540-A | The manufacturing method of lithium nickel composite oxide | 住友化学株式会社 | 2019-10-22 | — | — | CN | disclosed |
| CN-110192297-A | Positive active material for lithium secondary battery, positive electrode for lithium secondary battery and lithium secondary battery | 住友化学株式会社 | 2019-08-30 | — | — | CN | disclosed |
| CN-110072816-A | Lithium metal composite oxide power, positive active material for lithium secondary battery, positive electrode for lithium secondary battery and lithium secondary battery | 住友化学株式会社 | 2019-07-30 | — | — | CN | disclosed |
| CN-107555494-B | Nickel complex hydroxide and its manufacturing method, non-aqueous electrolyte secondary battery and its positive active material and the substance producing method | 住友金属矿山株式会社 | 2019-05-10 | — | — | CN | disclosed |
| CN-109643798-A | Positive active material for lithium secondary battery, positive electrode for lithium secondary battery and lithium secondary battery | 住友化学株式会社 | 2019-04-16 | — | — | CN | disclosed |
| CN-109643797-A | Positive electrode active material for sodium ion secondary battery | 株式会社田中化学研究所 | 2019-04-16 | — | — | CN | disclosed |
| CN-109565045-A | Positive active material for lithium secondary battery, its manufacturing method and lithium secondary battery | 株式会社杰士汤浅国际 | 2019-04-02 | — | — | CN | disclosed |
| CN-109311699-A | Manufacturing method containing nickel hydroxide | 住友金属矿山株式会社 | 2019-02-05 | — | — | CN | disclosed |
| CN-109310977-A | Chemical reaction device and method for producing particles using chemical reaction device | 住友金属矿山株式会社 | 2019-02-05 | — | — | CN | disclosed |
| CN-105917500-A | Positive electrode active material for lithium secondary battery, positive electrode for lithium secondary battery, and lithium secondary battery | 住友化学株式会社 | 2016-08-31 | — | — | CN | disclosed |
| CN-102576869-B | Positive active material particle powder and manufacture method thereof and rechargeable nonaqueous electrolytic battery | TODA KOGYO CORP. (JP) | 2016-01-20 | — | — | CN | disclosed |
| CN-102985258-B | Image forming apparatus and recording liquid | RICOH CO LTD | 2015-03-18 | — | — | CN | disclosed |
| CN-104247100-A | POSITIVE ELECTRODE ACTIVE MATERIAL PARTICLE POWDER AND METHOD FOR PRODUCING SAME, AND NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY | TODA KOGYO CORP | 2014-12-24 | — | — | CN | disclosed |
| CN-103797623-A | Nickel composite hydroxide and method for producing same, positive electrode active material for nonaqueous electrolyte secondary battery and method for producing same, and nonaqueous electrolyte secondary battery | SUMITOMO METAL MINING CO | 2014-05-14 | — | — | CN | disclosed |
| CN-103460456-A | Positive electrode active material granular powder and method for producing same, and nonaqueous electrolyte secondary battery | TODA KOGYO CORP | 2013-12-18 | — | — | CN | disclosed |
| CN-102985258-A | Image forming apparatus and recording liquid | RICOH CO LTD | 2013-03-20 | — | — | CN | disclosed |
| CN-102576869-A | Positive electrode active material powder, method for producing same, and nonaqueous electrolyte secondary battery | TODA KOGYO CORP | 2012-07-11 | — | — | CN | disclosed |
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |