Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Uracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.74 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL4652740 | 1.00 | CRBN (0.74) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL2895220 | 0.98 | CRBN (0.71) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL9429688 | 0.89 | CRBN (0.77) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL25208560 | 0.88 | CRBN (0.63) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL2895224 | 0.88 | CRBN (0.68) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL11607890 | 0.86 | — | — | |
| Uracil SCHEMBL8235 | 0.86 | — | — | |
| Uracil SCHEMBL3798527 | 0.86 | CRBN (1.00) | CRBNMMP2TP53ALDH1A1LMNA | |
| Uracil SCHEMBL5089507 | 0.86 | — | — | |
| Uracil SCHEMBL21385227 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101104608-B | Solanesol derivative, preparation and application thereof | UNIV HENAN | 2011-05-04 | — | — | CN | claimed |
| CN-101104608-A | Solanesol derivative, preparation and application thereof | UNIV HENAN (CN) | 2008-01-16 | — | — | CN | claimed |
| US-20250281627-A1 | CANCER-TARGETING PEPTIDE, PRODRUG NANOPARTICLES COMPRISING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR CANCER PREVENTION OR TREATMENT | NOXPHARM CO., LTD. (KR) | 2025-09-11 | — | — | US | disclosed |
| WO-2025038588-A1 | NANOPARTICLES, THEIR PREPARATION AND USE | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2025-02-20 | — | — | WO | disclosed |
| WO-2024111844-A1 | CANCER-TARGETING PEPTIDE, PRODRUG NANOPARTICLES COMPRISING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR CANCER PREVENTION OR TREATMENT | 이화여자대학교 산학협력단 | 2024-05-30 | — | — | WO | disclosed |
| CN-113845483-B | Pink back pteridonic acid and 5-fluorouracil hybrid, preparation method and application thereof | 安徽工业大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-110256361-B | Bishydrazide compound containing phenylpyrimidinone structural fragment and preparation method thereof | 湖南人文科技学院 | 2023-06-16 | — | — | CN | disclosed |
| CN-111171041-B | 20-substituted camptothecin derivative and preparation method and application thereof | 中国海洋大学 | 2021-07-27 | — | — | CN | disclosed |
| US-10849733-B2 | Glucose-responsive artificial muscle and manufacturing method therefor | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2020-12-01 | — | — | US | disclosed |
| CN-111171041-A | 20-substituted camptothecin derivative and preparation method and application thereof | 中国海洋大学 | 2020-05-19 | — | — | CN | disclosed |
| CN-110256361-A | A kind of bishydrazide compounds and preparation method thereof of the structure fragment of ketone containing phenyl pyrimidine | 湖南人文科技学院 | 2019-09-20 | — | — | CN | disclosed |
| WO-2007104979-A1 | VIRUS-LIKE PARTICLES OF RIFT VALLEY FEVER VIRUS | LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE (GB) | 2007-09-20 | — | — | WO | disclosed |
| US-20040093638-A1 | Method for promoting fatty acid synthesis in a plant | NARA INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) | 2004-05-13 | — | — | US | disclosed |
| EP-1241262-A2 | A method for promoting fatty acid synthesis in a plant | Nara Institute of Science and Technology (JP) | 2002-09-18 | — | — | EP | disclosed |
| WO-1999014216-A1 | SUBSTITUTED 3(-1,2-BENZISOTHIAZOL OR ISOXAZOL-5 YL)-SUBSTITUTED PYRIMIDINE AS HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1999-03-25 | — | — | WO | disclosed |
| EP-0540707-B1 | Di(2-PROPYL)ESTERS OF 1-FLUORO-2-PHOSPHONOMETHOXY-3-P-TOLUENESULFONYLOXYPROPANES, THEIR PRODUCING AND UTILIZATION | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1995-11-15 | — | — | EP | disclosed |
| US-5352786-A | Di(2-propyl)esters of 1-fluoro-2-phosphonomethoxy-3-P-to-luenesulfonyloxypropanes, their producing and utilization | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1994-10-04 | — | — | US | disclosed |
| EP-0540707-A1 | Di(2-PROPYL)ESTERS OF 1-FLUORO-2-PHOSPHONOMETHOXY-3-P-TOLUENESULFONYLOXYPROPANES, THEIR PRODUCING AND UTILIZATION. | CESKOSLOVENSKA AKADEMIE VED (CS) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992020692-A1 | DI(2-PROPYL)ESTERS OF 1-FLUORO-2-PHOSPHONOMETHOXY-3-P-TOLUENESULFONYLOXYPROPANES, THEIR PRODUCING AND UTILIZATION | GILEAD SCIENCES, INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| WO-1992020691-A1 | Di(2-PROPYL)ESTERS OF 1-FLUORO-2-PHOSPHONOMETHOXY-3-P-TOLUENESULFONYLOXYPROPANES, THEIR PRODUCING AND UTILIZATION | C^¿ESKOSLOVENSKÁ AKADEMIE VE^¿D (CS) | 1992-11-26 | — | — | WO | disclosed |