Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429795 | 0.91 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL9429984 | 0.91 | SLC6A4 (0.39) | CDK2AP1CHEK1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9428841 | 0.90 | HSD17B1 (0.38) | HSD17B1HSD17B2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9429749 | 0.89 | EP300 (0.35) | SLC6A4SLC6A2SLC6A3KCNH2MMP13 | |
| SCHEMBL9428532 | 0.89 | MCHR1 (0.40) | CDK2AP1CHEK1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9429644 | 0.89 | APP (0.37) | CHEK1HSD17B1HSD17B2TRPM8MMP13 | |
| SCHEMBL9428671 | 0.88 | MMP13 (0.33) | SLC6A4SLC6A2SLC6A3KCNH2MMP13 | |
| SCHEMBL9429264 | 0.87 | PRF1 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2RAB9A | |
| SCHEMBL9429149 | 0.86 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL9428834 | 0.85 | SLC6A4 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |