Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17940741 | 0.88 | PI4KA (0.46) | TSHRKDM4EPI4KAPI4K2BPI4K2A | |
| SCHEMBL15389431 | 0.80 | CYP17A1 (0.66) | CYP1A2CYP17A1 | |
| SCHEMBL9429053 | 0.79 | CYP19A1 (0.37) | TSHRKDM4ESMN1; SMN2HIF1AMAPT | |
| SCHEMBL840022 | 0.78 | HTT (0.51) | KDM4ECYP1A2L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL28252193 | 0.78 | ALDH1A1 (0.44) | KDM4ECYP1A2SMN1; SMN2HIF1AMAPT | |
| SCHEMBL9428481 | 0.75 | TSHR (0.46) | TSHRKDM4ECYP1A2SMN1; SMN2HIF1A | |
| SCHEMBL17691571 | 0.73 | HTT (0.56) | CYP17A1ALDH1A1MAPK1 | |
| SCHEMBL17940689 | 0.72 | CYP17A1 (0.39) | TSHRCYP17A1LCKGABRA1GABRG2 | |
| SCHEMBL17940706 | 0.72 | HTT (0.51) | PI4KAPI4K2BPI4K2API4KBGABRA1 | |
| SCHEMBL17940726 | 0.71 | HCAR1 (0.41) | KDM4ECYP17A1LCKGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374615-A | Treating hypertension and congestive heart failure, preventing cardiac hypertrophy | E. R. SQUIBB & SONS, INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0547827-A1 | Indole and benzimidazole-substituted dihydropyrimidine derivatives useful as A-II receptors antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-06-23 | — | — | EP | disclosed |
| US-5212177-A | INDOLE AND BENZIMIDAZOLE-SUBSTITUTED DIHYDROPYRIMIDINE DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1993-05-18 | — | — | US | disclosed |
| EP-0488532-A1 | Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives | E.R. Squibb & Sons, Inc. (US) | 1992-06-03 | — | — | EP | disclosed |