SCHEMBL9430288

SCHEMBL9430288

O=C(O)CCC(Cl)C(Cl)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 11/20 0.52
TET2 Q6N021 3/20 0.48
KDM4A O75164 2/20 0.48
KDM4C Q9H3R0 2/20 0.48
KDM2A Q9Y2K7 2/20 0.48
TET3 O43151 1/20 0.48
CYP1A2 P05177 2/20 0.46
GRM3 Q14832 2/20 0.46
GRM8 O00222 1/20 0.46
GRM6 O15303 1/20 0.46
GRIN2D O15399 1/20 0.46
GRIN3B O60391 1/20 0.46
GSR P00390 1/20 0.46
GRIK1 P39086 1/20 0.46
GRM5 P41594 1/20 0.46
GRIA1 P42261 1/20 0.46
GRIA2 P42262 1/20 0.46
GRIA3 P42263 1/20 0.46
SLC1A3 P43003 1/20 0.46
SLC1A2 P43004 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10893370 0.82 TSHR (0.50) TSHRHSD17B10
SCHEMBL11682223 0.82 TSHR (0.50) TSHRHSD17B10
SCHEMBL28544266 0.79 FOLH1 (0.50) FOLH1TET2KDM4AKDM4CKDM2A
SCHEMBL25269744 0.77 LMNA (0.38) FOLH1TSHR
SCHEMBL6517678 0.75 CHRM1 (0.50) GRIK1SLC1A3SLC1A2SLC1A1GRIK2
SCHEMBL1132263 0.75 GABRP (0.52) FOLH1TET2KDM4AKDM4CKDM2A
SCHEMBL2961393 0.74 TDP1 (0.46) FOLH1TSHR
SCHEMBL30945133 0.74 FOLH1 (0.56) FOLH1TET2KDM4AKDM4CKDM2A
SCHEMBL3086060 0.74 FOLH1 (0.56) FOLH1TET2KDM4AKDM4CKDM2A
SCHEMBL898838 0.73 LMNA (0.35) FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1047379-C Process for preparing alpha, alpha'-dichloro-hexandioic acid DALIAN CHEMICAL RESEARCH AND D (CN) 1999-12-15 CN claimed
CN-1153165-A Process for preparing alpha, alpha'-dichloro-hexandioic acid DALIAN RESEARCH & DESIGN INST (CN) 1997-07-02 CN claimed
US-4042571-A Fire-retardant polyamides from naphthalene dicarboxylic reactant and halogenated carboxylic reactant TEIJIN LIMITED (JA) 1977-08-16 US claimed
CN-1047379-C Process for preparing alpha, alpha'-dichloro-hexandioic acid DALIAN CHEMICAL RESEARCH AND D (CN) 1999-12-15 CN disclosed
CN-1153165-A Process for preparing alpha, alpha'-dichloro-hexandioic acid DALIAN RESEARCH & DESIGN INST (CN) 1997-07-02 CN disclosed
CN-1153165-A Process for preparing alpha, alpha'-dichloro-hexandioic acid DALIAN RESEARCH & DESIGN INST (CN) 1997-07-02 CN disclosed
US-5310940-A Sulfiding, cyclization SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1994-05-10 US disclosed
US-5093504-A PRODUCTION OF THIOPHENE-2,5-DICARBOXYLIC ACID DIESTERS, TETRAHYDROTHIOPHENE-2,5-DICARBOXYLIC ACID DIESTERS AND DIBENZOXAZOLYLTHIOPHENES SUMITOMO SEIKA CHEMICALS, CO., LTD. (JP) 1992-03-03 US disclosed
EP-0387725-A2 Production of thiophene-2,5-dicarboxylic acid diesters and tetrahydrothiophene-2,5-dicarboxylic acid diesters SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1990-09-19 EP disclosed
US-4933465-A Magenta coupler CHEIL SYNTHETIC TEXTILE CO., LTD. (KR) 1990-06-12 US disclosed
US-4092226-A PLATING CHROMIUM FROM HALOGEN CONTAINING BATH LAING NIKOLAUS 1978-05-30 US disclosed
US-4042571-A Fire-retardant polyamides from naphthalene dicarboxylic reactant and halogenated carboxylic reactant TEIJIN LIMITED (JA) 1977-08-16 US disclosed