Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21060542 | 0.82 | CSNK2A1 (0.49) | CTRCCYP2A6ALDH1A1KMT2AKDM4E | |
| SCHEMBL29561544 | 0.82 | CCR1 (0.42) | CTRCCYP2A6ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL8308121 | 0.82 | CCR1 (0.42) | CTRCCYP2A6ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7905040 | 0.77 | CYP2A6 (0.44) | CTRCCYP2A6ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL29561568 | 0.74 | ADH1B (0.44) | CTRCCYP2A6CSNK2A1 | |
| SCHEMBL21060544 | 0.74 | ADH1B (0.44) | CTRCCYP2A6CSNK2A1 | |
| SCHEMBL8305228 | 0.73 | DHODH (0.54) | CYP2A6ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL21060556 | 0.73 | MEN1 (0.50) | ALDH1A1L3MBTL1KMT2AKDM4EMEN1 | |
| SCHEMBL29561587 | 0.73 | MEN1 (0.50) | ALDH1A1L3MBTL1KMT2AKDM4EMEN1 | |
| SCHEMBL5376937 | 0.69 | MEN1 (0.60) | ALDH1A1L3MBTL1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994011378-A1 | ARYL THIOPYRANO[2,3,4-c,d]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-05-26 | — | — | WO | disclosed |
| US-5314900-A | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-24 | — | — | US | disclosed |
| US-5202321-A | Antihistamine, antiallergens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1993-04-13 | — | — | US | disclosed |
| EP-0518426-A1 | Thiopyrano (2,3,4-c,d) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-12-16 | — | — | EP | disclosed |