Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430131 | 0.99 | ADORA2A (0.56) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL9430619 | 0.95 | ADORA2A (0.61) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL10856971 | 0.88 | SIRT1 (0.61) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10859893 | 0.88 | SIRT1 (0.61) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1063544 | 0.88 | SIRT1 (0.68) | ADORA2AADORA2BSIRT1SIRT3SIRT5 | |
| SCHEMBL9430349 | 0.85 | PDE1A (0.67) | ADORA2AADORA2BSIRT1SIRT3SIRT5 | |
| SCHEMBL7918903 | 0.85 | ADORA1 (0.57) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL18834910 | 0.81 | PDE2A (0.53) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL11066305 | 0.81 | SIRT1 (0.54) | ADORA2AADORA2BSIRT1SIRT3SIRT5 | |
| SCHEMBL9430688 | 0.81 | PDE1A (0.68) | ADORA2AADORA2BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269841-B1 | 1-HYDROXYALKYL XANTHINES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1992-11-11 | — | — | EP | claimed |
| EP-0269841-A1 | 1-Hydroxyalkyl xanthines, processes for their preparation and medicaments containing them | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1988-06-08 | — | — | EP | claimed |
| US-5338741-A | Cardiotonic agents | NESTEC S.A. (CH) | 1994-08-16 | — | — | US | disclosed |
| EP-0269841-B1 | 1-HYDROXYALKYL XANTHINES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1992-11-11 | — | — | EP | disclosed |
| US-5053433-A | Photodiesterase inhibitor | SOCIETE ANONYME DITE: L'OREAL (FR) | 1991-10-01 | — | — | US | disclosed |
| EP-0269841-A1 | 1-Hydroxyalkyl xanthines, processes for their preparation and medicaments containing them | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1988-06-08 | — | — | EP | disclosed |