Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8691754 | 0.85 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ATSHRCA2 | |
| SCHEMBL8934937 | 0.82 | TSHR (0.63) | EPHX2NR1H4ALDH1A1PKMMEN1 | |
| Hydrochloric Acid SCHEMBL28761138 | 0.81 | ALDH1A1 (0.50) | NR1H4ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL10968223 | 0.76 | TSHR (0.50) | ALDH1A1MEN1KMT2ATSHRCA2 | |
| SCHEMBL5445025 | 0.72 | HTT (0.51) | EPHX2NR1H4ALDH1A1PKMMEN1 | |
| Acedoben SCHEMBL24320 | 0.71 | ALDH1A1 (0.68) | EPHX2NR1H4ALDH1A1MEN1KMT2A | |
| SCHEMBL4745756 | 0.71 | EPHX2 (0.71) | EPHX2NR1H4ALDH1A1MEN1KMT2A | |
| SCHEMBL9555249 | 0.71 | ALDH1A1 (0.61) | EPHX2NR1H4ALDH1A1PKMMEN1 | |
| SCHEMBL1066727 | 0.70 | MAPT (0.59) | ALDH1A1CA2CA12CA9CA1 | |
| Hydrochloric Acid SCHEMBL7563130 | 0.70 | EPHX2 (0.47) | EPHX2NR1H4ALDH1A1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310752-A | Distamycin A analogs; antitumor agents, viricides | FARMITALIA CARLO ERBA SPA (IT) | 1994-05-10 | — | — | US | disclosed |
| EP-0246868-B1 | SITE SPECIFIC ALKYLATING AGENTS | FARMITALIA CARLO ERBA S.r.l. (IT) | 1992-09-16 | — | — | EP | disclosed |
| US-5017599-A | Antitumor, antiviral distamycin A analog | FARMITALIA CARLO ERBA, SPA (IT) | 1991-05-21 | — | — | US | disclosed |
| EP-0246868-A1 | Site specific alkylating agents | FARMITALIA CARLO ERBA S.r.l. (IT) | 1987-11-25 | — | — | EP | disclosed |