Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430588 | 0.95 | SIRT2 (0.51) | SIRT2PARP10PARP15MAOBLRRK2 | |
| SCHEMBL15709261 | 0.87 | PARP15 (0.60) | SIRT2PARP10PARP15MAOBL3MBTL1 | |
| SCHEMBL9430649 | 0.84 | MAOB (0.58) | MAOBL3MBTL1LRRK2 | |
| SCHEMBL11282772 | 0.82 | SIRT2 (0.53) | SIRT2PARP10PARP15MAOBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL320730 | 0.81 | SIRT2 (0.52) | SIRT2PARP10PARP15MAOBL3MBTL1 | |
| SCHEMBL9431017 | 0.80 | MAOB (0.49) | MAOBL3MBTL1LMNAKDM4EMEN1 | |
| SCHEMBL19068931 | 0.80 | MAOB (0.51) | MAOBL3MBTL1LMNAKDM4EMEN1 | |
| SCHEMBL4930554 | 0.80 | PARP10 (0.60) | SIRT2PARP10PARP15MAOBL3MBTL1 | |
| SCHEMBL12502510 | 0.80 | KDM4E (0.51) | SIRT2PARP10MAOBL3MBTL1LRRK2 | |
| SCHEMBL6140955 | 0.79 | PARP15 (0.75) | SIRT2PARP10PARP15MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5347050-A | Cardioselective adrenoreceptor blocking agents; prophylaxis and therapy for coronary diseases, glaucoma, migraine | BERTHOLD RICHARD (CH) | 1994-09-13 | — | — | US | disclosed |
| EP-0052072-B1 | 3-AMINOPROPOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ AG (CH) | 1985-02-20 | — | — | EP | disclosed |
| US-4425362-A | CARDIOVASCULAR DISORDERS, ADRENERGIC BLOCKING AGENTS | SANDOZ LTD. (CH) | 1984-01-10 | — | — | US | disclosed |