SCHEMBL9431982

SCHEMBL9431982

C=C1c2ccccc2C(=O)C1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.55
HTT P42858 6/20 0.55
HBB P68871 2/20 0.55
ALOX15 P16050 1/20 0.55
MEN1 O00255 9/20 0.50
KMT2A Q03164 9/20 0.50
THRB P10828 2/20 0.50
ADORA3 P0DMS8 1/20 0.50
CHRM1 P11229 1/20 0.50
TBXA2R P21731 1/20 0.50
PTGS1 P23219 1/20 0.50
ADRA1A P35348 1/20 0.50
ALDH1A1 P00352 2/20 0.48
HSD17B10 Q99714 1/20 0.48
LMNA P02545 8/20 0.47
KDM4E B2RXH2 8/20 0.47
RAB9A P51151 4/20 0.47
NPC1 O15118 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.47
SLC25A5 P05141 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8893921 0.85 MAPT (0.65) MAPTHTTHBBALOX15MEN1
SCHEMBL11509568 0.72 MAPT (0.50) MAPTHTTHBBALOX15MEN1
SCHEMBL11451081 0.71 MAPT (1.00) MAPTHTTHBBALOX15MEN1
SCHEMBL9403263 0.71 MAPT (0.54) MAPTHTTHBBALOX15MEN1
SCHEMBL29541198 0.70 MAPT (0.57) MAPTHTTHBBALOX15MEN1
SCHEMBL2112664 0.70 HBB (0.61) MAPTHTTHBBALOX15MEN1
SCHEMBL6684295 0.68 MAPT (0.46) MAPTHTTHBBALOX15MEN1
SCHEMBL10930218 0.68 EDNRA (0.56) MAPTHTTHBBALOX15MEN1
SCHEMBL40500 0.67 HDAC3 (0.59) MAPTHTTHBBALOX15MEN1
Benzene SCHEMBL28538497 0.67 HDAC3 (0.59) MAPTHTTHBBALOX15MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994014788-A1 NOVEL DERIVATIVES OF A FIVE-MEMBERED RING FUSED BENZENE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Richter Gedeon Vegyészeti Gyár Rt. (HU) 1994-07-07 WO disclosed