Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 5/20 | 0.38 |
| ▸ | BACE1 | P56817 | 5/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1569539 | 0.90 | AKR1B1 (0.36) | AKR1B1AKR1B10MAPTAKR1A1APP | |
| SCHEMBL11170633 | 0.84 | MAP3K14 (0.39) | APPBACE1 | |
| SCHEMBL4521630 | 0.81 | ITGB2 (0.33) | KIF11 | |
| SCHEMBL29960675 | 0.81 | ITGB2 (0.33) | KIF11 | |
| SCHEMBL2777849 | 0.77 | BACE1 (0.33) | MAPTAPPBACE1 | |
| SCHEMBL769008 | 0.77 | KDM1A (0.43) | — | |
| SCHEMBL15919072 | 0.76 | LMNA (0.36) | MAPTAPPBACE1 | |
| SCHEMBL2776865 | 0.74 | PDE4A (0.31) | APPBACE1 | |
| SCHEMBL2129753 | 0.74 | FTO (0.35) | — | |
| SCHEMBL19126994 | 0.74 | KDM1A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0011426-B1 | HALOGEN-SUBSTITUTED BENZOPYRAN- AND BENZOTHIOPYRAN-4-CARBOXYLIC ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PFIZER INC. (US) | 1983-06-22 | — | — | EP | disclosed |
| US-4210663-A | ALDOSE REDUCTASE INHIBITORS; TREATMENT OF DIABETIC CATARACTS, NEUROPATHY OR RETINOPATHY | PFIZER INC. (US) | 1980-07-01 | — | — | US | disclosed |
| EP-0011426-A1 | Halogen-substituted benzopyran- and benzothiopyran-4-carboxylic acids, their preparation and pharmaceutical compositions containing the same | PFIZER INC. (US) | 1980-05-28 | — | — | EP | disclosed |