Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750006 | 0.86 | HRH3 (0.50) | SMN1; SMN2SIGMAR1HRH3CYP1A2MAPK1 | |
| SCHEMBL42534 | 0.85 | KDM4E (0.50) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL42822 | 0.81 | HRH3 (0.55) | SMN1; SMN2SIGMAR1HRH3CYP1A2MAPK1 | |
| SCHEMBL4042395 | 0.81 | KEAP1 (0.62) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL6593644 | 0.81 | HRH3 (0.42) | SMN1; SMN2SIGMAR1POLBALDH1A1HRH3 | |
| SCHEMBL42493 | 0.79 | HRH3 (0.59) | SMN1; SMN2SIGMAR1POLBALDH1A1HRH3 | |
| SCHEMBL30596603 | 0.79 | SMN1; SMN2 (0.60) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL1998867 | 0.78 | KEAP1 (0.71) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| SCHEMBL17377315 | 0.77 | KEAP1 (0.62) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 | |
| Ammonia Solution, Strong SCHEMBL9400430 | 0.76 | KEAP1 (0.68) | KEAP1SMN1; SMN2HPGDDUSP3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5358949-A | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-25 | — | — | US | disclosed |
| EP-0236140-A2 | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-09 | — | — | EP | disclosed |