Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28671248 | 0.76 | NPC1 (0.53) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9281450 | 0.73 | RAB9A (0.41) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL6902568 | 0.72 | NPC1 (0.63) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9431965 | 0.72 | RAB9A (0.40) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL6008059 | 0.71 | MAPT (0.58) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9682726 | 0.71 | RAB9A (0.39) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9681875 | 0.70 | MAPT (0.37) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL9432441 | 0.70 | RAB9A (0.43) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL2736597 | 0.69 | CNR2 (0.45) | RAB9ANPC1MAPTTP53SMN1; SMN2 | |
| SCHEMBL6981618 | 0.69 | NPC1 (0.54) | RAB9ANPC1MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308854-A | 2-benzoxazolylalkyl substituted pyridin-2(1H)(thi)ones; AIDS | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| EP-0484071-A2 | Synergism of HIV reverse transcriptase inhibitors | MERCK & CO. INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |