Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434613 | 0.90 | KDM4E (0.61) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL9433779 | 0.87 | POLB (0.47) | KDM4EHSD17B10ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9433540 | 0.86 | KDM4E (0.45) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL9433568 | 0.85 | KDM4E (0.44) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL9434846 | 0.84 | ALDH1A1 (0.43) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL9434790 | 0.84 | KDM4E (0.43) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL9433813 | 0.84 | KDM4E (0.43) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL9434205 | 0.83 | CACNA1B (0.52) | — | |
| SCHEMBL9434185 | 0.83 | CACNA1B (0.52) | — | |
| SCHEMBL9806975 | 0.83 | MAPT (0.56) | KDM4EHSD17B10ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |