Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 10/20 | 0.37 |
| ▸ | MAOA | P21397 | 9/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744814 | 0.71 | NPC1 (0.40) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL4104017 | 0.66 | CA9 (0.52) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL28402480 | 0.66 | CA9 (0.38) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL2220790 | 0.65 | CA9 (0.42) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL1744197 | 0.65 | NPC1 (0.43) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL29754281 | 0.63 | CA9 (0.62) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL986343 | 0.63 | NPC1 (0.55) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL4102521 | 0.63 | CA9 (0.62) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL2221081 | 0.63 | CA9 (0.57) | CA9NPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL29754234 | 0.63 | CA9 (0.57) | CA9NPC1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | claimed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |