Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 18/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21028439 | 1.00 | FDPS (0.45) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10341436 | 1.00 | FDPS (0.45) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10341385 | 0.98 | FDPS (0.47) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL21028441 | 0.89 | FDPS (0.48) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10341390 | 0.74 | FDPS (0.41) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL5059577 | 0.72 | TSHR (0.52) | LMNATSHRCYP2C19 | |
| SCHEMBL7028133 | 0.69 | FDPS (0.37) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL20763861 | 0.67 | — | — | |
| SCHEMBL20763853 | 0.67 | — | — | |
| SCHEMBL18822640 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719203-A | CALCIUM METABOLISM DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1988-01-12 | — | — | US | claimed |
| EP-0586521-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021355-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0224751-B1 | DIPHOSPHONIC-ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1990-01-24 | — | — | EP | disclosed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | disclosed |
| US-4719203-A | CALCIUM METABOLISM DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1988-01-12 | — | — | US | disclosed |
| EP-0224751-A1 | Diphosphonic-acid derivatives, process for preparing them and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |