Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL9436280

N.O=C(O)/C=C\C(=O)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.53
KMT2A Q03164 6/20 0.51
ALDH1A1 P00352 4/20 0.51
MEN1 O00255 4/20 0.51
TDP1 Q9NUW8 2/20 0.51
MAPT P10636 2/20 0.51
KDM4E B2RXH2 1/20 0.51
POLB P06746 1/20 0.51
BCL9 O00512 1/20 0.50
CTNNB1 P35222 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49
PKM P14618 1/20 0.49
SRD5A2 P31213 1/20 0.46
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CES2 O00748 1/20 0.45
CES1 P23141 1/20 0.45
MGLL Q99685 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL9436297 1.00 GAA (0.53) GAAKMT2AALDH1A1MEN1TDP1
SCHEMBL2108301 0.98 GAA (0.54) GAAKMT2AALDH1A1MEN1TDP1
SCHEMBL4296577 0.98 GAA (0.54) GAAKMT2AALDH1A1MEN1TDP1
SCHEMBL4661270 0.91 GAA (0.61) GAAKMT2AALDH1A1MEN1MAPT
SCHEMBL956911 0.91 GAA (0.61) GAAKMT2AALDH1A1MEN1MAPT
SCHEMBL31119075 0.88 GAA (0.48) GAAKMT2AALDH1A1MEN1TDP1
SCHEMBL12858124 0.83 ACHE (0.60) GAAKMT2AALDH1A1MEN1MAPT
SCHEMBL17695797 0.83 GAA (0.57) GAAKMT2AALDH1A1MEN1MAPT
SCHEMBL9359869 0.83 GAA (0.53) GAAKMT2AALDH1A1MEN1MAPT
SCHEMBL11973529 0.81 GAA (0.58) GAAKMT2AALDH1A1MAPTBCL9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5376145-A Using esters, salts amd amides of maleic or fumaric acid in aqueous solution; preventing loss of bulk COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 1994-12-27 US disclosed
EP-0393037-B1 TREATMENTS TO IMPROVE THE PROPERTIES OF KERATINOUS TEXTILES COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1993-06-09 EP disclosed
EP-0393037-A4 TREATMENTS TO IMPROVE THE PROPERTIES OF KERATINOUS TEXTILES 1991-03-13 EP disclosed
EP-0393037-A1 TREATMENTS TO IMPROVE THE PROPERTIES OF KERATINOUS TEXTILES. COMMW SCIENT IND RES ORG (AU) 1990-10-24 EP disclosed
WO-1989001541-A1 TREATMENTS TO IMPROVE THE PROPERTIES OF KERATINOUS TEXTILES COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR (AU) 1989-02-23 WO disclosed