Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230507 | 0.89 | KDM4E (0.55) | PKMKDM4EHSD17B10P2RX4ALDH1A1 | |
| SCHEMBL11446022 | 0.86 | PKM (0.66) | PKMKDM4EHSD17B10P2RX4ALDH1A1 | |
| SCHEMBL8065979 | 0.85 | TTR (0.48) | PKMKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL21962198 | 0.83 | PKM (0.74) | PKMALDH1A1HPGDCA2CA1 | |
| SCHEMBL15524940 | 0.82 | CA12 (0.54) | PKMP2RX4F10CA2CA1 | |
| SCHEMBL21814405 | 0.81 | CA2 (0.55) | PKMKDM4EHSD17B10P2RX4ALDH1A1 | |
| SCHEMBL2684958 | 0.80 | USP2 (0.76) | PKMKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL31748192 | 0.80 | HPGD (0.54) | PKMKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL8068832 | 0.80 | PKM (0.43) | PKMALDH1A1HPGDUSP2F10 | |
| SCHEMBL9196597 | 0.80 | P2RX4 (0.47) | PKMKDM4EHSD17B10P2RX4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |