Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | GSTO1 | P78417 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488862 | 0.88 | TSHR (0.57) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL11595745 | 0.83 | GSTO1 (0.57) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL1495456 | 0.83 | ALDH1A1 (0.65) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL1495720 | 0.83 | ALDH1A1 (0.65) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL11596061 | 0.83 | KMT2A (0.70) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL11596069 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL3865205 | 0.81 | ALDH1A1 (0.63) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL11339928 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL13543287 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL15880442 | 0.80 | ALDH1A1 (0.62) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |