SCHEMBL9436830

SCHEMBL9436830

C=CC(=O)NC(C)(C)CC=CC(=O)O

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
TSHR P16473 3/20 0.33
TDP1 Q9NUW8 2/20 0.33
GABRR1 P24046 2/20 0.33
GABRR2 P28476 2/20 0.33
BLM P54132 2/20 0.33
LMNA P02545 2/20 0.33
MAPK1 P28482 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GABRR3 A8MPY1 1/20 0.33
APEX1 P27695 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
ZDHHC20 Q5W0Z9 1/20 0.30
ZDHHC2 Q9UIJ5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20381578 0.84 ALDH1A1 (0.44) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
SCHEMBL6247311 0.77 ALDH1A1 (0.35) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
SCHEMBL6319693 0.75 TSHR (0.39) ALDH1A1TSHRTDP1GABRR1GABRR2
Maleic Acid SCHEMBL8645980 0.75 ALDH1A1 (0.43) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
Fumaric Acid SCHEMBL8645982 0.75 ALDH1A1 (0.43) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
SCHEMBL6319691 0.75 TSHR (0.39) ALDH1A1TSHRTDP1GABRR1GABRR2
SCHEMBL35674 0.75 ALDH1A1 (0.56) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
Maleic Acid SCHEMBL2839159 0.75 ALDH1A1 (0.45) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
Fumaric Acid SCHEMBL5315241 0.75 ALDH1A1 (0.45) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1
SCHEMBL19860763 0.74 ALDH1A1 (0.55) ALDH1A1CYP3A4CYP2C9CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5275809-A Nonionic acrylamide monomer; cationic dimethydiallylammonium chloride monomer; anionic 2-acrylamido-2-methylpropane sulfonic acid monomer CALGON CORPORATION (US) 1994-01-04 US claimed
US-5275809-A Nonionic acrylamide monomer; cationic dimethydiallylammonium chloride monomer; anionic 2-acrylamido-2-methylpropane sulfonic acid monomer CALGON CORPORATION (US) 1994-01-04 US disclosed