Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5315241 | 1.00 | ALDH1A1 (0.45) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| Acrylic Acid SCHEMBL859839 | 0.93 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| Crotonic Acid SCHEMBL30355324 | 0.92 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL19490 | 0.92 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL28723020 | 0.92 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL12002785 | 0.90 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| Iodide SCHEMBL7702886 | 0.90 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL121582 | 0.90 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| Water SCHEMBL10732835 | 0.90 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL8149086 | 0.90 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9254550-B2 | Surface coating processes and uses of same | HKPB SCIENTIFIC LIMITED (IE) | 2016-02-09 | — | — | US | disclosed |
| US-9149911-B2 | Processes and apparatus for surface modification | HKPB SCIENTIFIC LIMITED (IE) | 2015-10-06 | — | — | US | disclosed |
| EP-2731732-A1 | PROCESSES AND APPARATUS FOR SURFACE MODIFICATION | HKPB Scientific Limited (IE) | 2014-05-21 | — | — | EP | disclosed |
| WO-2013007840-A1 | PROCESSES AND APPARATUS FOR SURFACE MODIFICATION | HKPB SCIENTIFIC LIMITED (IE) | 2013-01-17 | — | — | WO | disclosed |
| EP-2219823-A2 | SURFACE COATING PROCESSES AND USES OF SAME | HKPB Scientific Limited (IE) | 2010-08-25 | — | — | EP | disclosed |
| US-20100211158-A1 | SURFACE COATING PROCESSES AND USES OF SAME | HKPB SCIENTIFIC LIMITED (IE) | 2010-08-19 | — | — | US | disclosed |
| WO-2009050251-A2 | SURFACE COATING PROCESSES AND USES OF SAME | HKPB SCIENTIFIC LIMITED (IE) | 2009-04-23 | — | — | WO | disclosed |
| EP-1488774-B1 | Polymer compositions and processes for preparing polymers | ROHM & HAAS (US) | 2007-03-14 | — | — | EP | disclosed |
| US-7160970-B2 | Process for manufacturing polymers | ROHM AND HAAS COMPANY (US) | 2007-01-09 | — | — | US | disclosed |
| US-20050107546-A1 | Process for manufacturing polymers | ROHM AND HAAS COMPANY | 2005-05-19 | — | — | US | disclosed |
| EP-1530962-A1 | Process for manufacturing polymers | ROHM AND HAAS COMPANY (US) | 2005-05-18 | — | — | EP | disclosed |
| US-20040258648-A1 | Polymer compositions and process for preparing polymers | CREAMER MARIANNE PATRICIA (US) | 2004-12-23 | — | — | US | disclosed |
| EP-1488774-A2 | Polymer compositions and processes for preparing polymers | ROHM AND HAAS COMPANY (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-0308221-B1 | COMPOSITION SUITABLE FOR USE AS, OR IN, AN ACIDIC RINSE AID | ROHM AND HAAS COMPANY (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0308221-A1 | Composition suitable for use as, or in, an acidic rinse aid | ROHM AND HAAS COMPANY (US) | 1989-03-22 | — | — | EP | disclosed |