Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437719 | 0.92 | HTR1A (0.52) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437779 | 0.83 | HTR1A (0.49) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437849 | 0.81 | HTR1A (0.48) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL13406065 | 0.81 | HTR1A (0.52) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437950 | 0.81 | HTR1A (0.45) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9452085 | 0.81 | HTR1A (0.47) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437911 | 0.81 | HTR1A (0.49) | HTR1AHTR2CGABRA5GABRA1 | |
| SCHEMBL8785675 | 0.80 | HTR1A (0.55) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437724 | 0.80 | HTR1A (0.55) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437737 | 0.80 | HTR1A (0.55) | HTR1AHTR2CHTR1DHTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |
| US-5225409-A | Serotoninergic disorders; anxiolytic agents; schizophrenia | ADIR ET COMPAGNIE (FR) | 1993-07-06 | — | — | US | disclosed |
| US-5196434-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-03-23 | — | — | US | disclosed |
| EP-0478446-A1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-01 | — | — | EP | disclosed |