Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.57 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTPRA | P18433 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439254 | 0.91 | BCL2 (0.56) | CTSKPTPN1 | |
| SCHEMBL9439184 | 0.90 | CTSK (0.55) | CTSKCTSSPTPN1PTPRA | |
| SCHEMBL9538641 | 0.89 | CTSK (0.59) | CTSKCTSS | |
| SCHEMBL9536550 | 0.89 | PTPN1 (0.59) | ACEPTPN1 | |
| SCHEMBL9538805 | 0.88 | CTSK (0.54) | CTSKCTSSACEPTPN1 | |
| SCHEMBL9439097 | 0.87 | CTSK (0.59) | CTSKCTSSCTSBPTPN1 | |
| SCHEMBL9439194 | 0.87 | PPARA (0.62) | CTSKCTSS | |
| SCHEMBL8685495 | 0.85 | CTSK (0.48) | CTSKCTSSCTSLCTSBACE | |
| SCHEMBL9538810 | 0.83 | CTSK (0.48) | CTSKCTSSPTPN1PTPRA | |
| SCHEMBL9438805 | 0.83 | CTSK (0.60) | CTSKCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346907-A | Cholecystokinin antagonists used in treatment or prevention of disorders of gastrointestinal, central nervous, appetite regulating or pain regulating systems | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0480969-A4 | AMINO ACID ANALOG CCK ANTAGONISTS | — | 1993-01-07 | — | — | EP | disclosed |
| EP-0480969-A1 | AMINO ACID ANALOG CCK ANTAGONISTS | ABBOTT LABORATORIES (US) | 1992-04-22 | — | — | EP | disclosed |
| WO-1991000725-A2 | AMINO ACID ANALOG CCK ANTAGONISTS | ABBOTT LABORATORIES (US) | 1991-01-24 | — | — | WO | disclosed |