SCHEMBL9439409

SCHEMBL9439409

O=P(Cl)(Nc1ccccc1)Nc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.50
RECQL P46063 1/20 0.50
HTT P42858 2/20 0.48
NPSR1 Q6W5P4 2/20 0.48
HPGD P15428 3/20 0.47
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
CA12 O43570 1/20 0.41
CA9 Q16790 1/20 0.41
ALDH1A1 P00352 3/20 0.41
TDP1 Q9NUW8 2/20 0.41
HSD17B10 Q99714 2/20 0.41
CTSD P07339 1/20 0.41
TSHR P16473 2/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
PTGS1 P23219 1/20 0.39
SLC6A2 P23975 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28384135 0.84 KDM4E (0.50) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL5013978 0.80 CA9 (0.48) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL27466881 0.78 RECQL (0.46) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL10797763 0.78 MEN1 (0.56) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL1491874 0.76 NPSR1 (0.56) KDM4ERECQLHTTNPSR1HPGD
Diphenylamine SCHEMBL27701247 0.76 HSD17B10 (0.67) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL239971 0.74 KDM4E (0.50) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL195068 0.74 CA9 (0.52) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL8081387 0.74 CA9 (0.52) KDM4ERECQLHTTNPSR1HPGD
SCHEMBL28253909 0.74 KDM4E (0.50) KDM4ERECQLHTTNPSR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292913-A Labeling with deuterium or tritium MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1994-03-08 US disclosed
EP-0262227-B1 PROCESS FOR THE PREPARATION OF MYOINOSITOL DERIVATIVES MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-01-20 EP disclosed
US-5026898-A Cell process controllers E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-06-25 US disclosed
US-4952717-A Myoinositol derivatives and preparation process thereof MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1990-08-28 US disclosed
US-4924023-A MEDICINE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-05-08 US disclosed
US-4873355-A Process for regioselectively preparing phosphorylated inositols and other cyclitols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-10-10 US disclosed
EP-0262227-A1 Process for the preparation of myoinositol derivatives MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-04-06 EP disclosed
US-4267174-A AND PROCESS FOR ADMINISTERING BOEHRINGER MANNHEIM, GMBH (DE) 1981-05-12 US disclosed