Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.44 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29600959 | 1.00 | DNM1 (0.52) | DNM1ALDH1A1LMNAKDM4EMEN1 | |
| Citric Acid SCHEMBL29600140 | 1.00 | DNM1 (0.52) | DNM1ALDH1A1LMNAKDM4EMEN1 | |
| Citric Acid SCHEMBL21219853 | 1.00 | DNM1 (0.52) | DNM1ALDH1A1LMNAKDM4EMEN1 | |
| Citric Acid SCHEMBL10888651 | 1.00 | DNM1 (0.52) | DNM1ALDH1A1LMNAKDM4EMEN1 | |
| Citric Acid SCHEMBL29562281 | 1.00 | DNM1 (0.52) | DNM1ALDH1A1LMNAKDM4EMEN1 | |
| Citric Acid SCHEMBL9814769 | 1.00 | DNM1 (0.52) | DNM1ALDH1A1LMNAKDM4EMEN1 | |
| Citric Acid SCHEMBL22556290 | 0.88 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4EMEN1CYP1A2 | |
| Citric Acid SCHEMBL10687560 | 0.87 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2ABLMHSPD1 | |
| Citric Acid SCHEMBL875432 | 0.87 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2ABLMHSPD1 | |
| Citric Acid SCHEMBL27042357 | 0.87 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2ABLMHSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356896-A | Alkaline stabiling medium | SANDOZ LTD. (CH) | 1994-10-18 | — | — | US | disclosed |
| US-5296627-A | Substituted butylene oxide-ethylene oxide copolymers | PPG INDUSTRIES, INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5162475-A | Copolymers with ethylenically unsaturated monomers; shrinkage inhibition of knit or non-woven fabrics | PPG INDUSTRIES, INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0422120-A4 | POLYMERIZABLE SURFACTANT | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422120-A1 | POLYMERIZABLE SURFACTANT | PPG INDUSTRIES, INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012618-A1 | POLYMERIZABLE SURFACTANT | PPG INDUSTRIES, INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0096103-B1 | PROCESS FOR MAKING IONIC STRUCTURED PARTICLE LATEXES USING REACTIVE POLYMERIC SURFACTANTS | THE DOW CHEMICAL COMPANY (US) | 1987-12-23 | — | — | EP | disclosed |
| EP-0096103-A2 | Process for making ionic structured particle latexes using reactive polymeric surfactants | THE DOW CHEMICAL COMPANY (US) | 1983-12-21 | — | — | EP | disclosed |
| US-4337185-A | WHEREIN IONS ARE CHEMICALLY BOUND ON SURFACES OF POLYMER PARTICLES | THE DOW CHEMICAL COMPANY (US) | 1982-06-29 | — | — | US | disclosed |
| US-4113710-A | EMULSION POLYMERIZATION | THE DOW CHEMICAL COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4056501-A | COPOLYMER | THE DOW CHEMICAL COMPANY (US) | 1977-11-01 | — | — | US | disclosed |
| US-4017372-A | Process for electrodeposition of cross-linked polymer coatings | THE DOW CHEMICAL COMPANY (US) | 1977-04-12 | — | — | US | disclosed |
| US-4017442-A | Structured-particle latexes | THE DOW CHEMICAL COMPANY (US) | 1977-04-12 | — | — | US | disclosed |