Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR1 | P15328 | 11/20 | 0.56 |
| ▸ | SLC46A1 | Q96NT5 | 9/20 | 0.56 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.56 |
| ▸ | GART | P22102 | 6/20 | 0.54 |
| ▸ | DHFR | P00374 | 3/20 | 0.43 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | FOLR2 | P14207 | 4/20 | 0.40 |
| ▸ | ATIC | P31939 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439656 | 1.00 | FOLR1 (0.56) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL9439960 | 0.93 | FOLR1 (0.57) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL9439954 | 0.93 | FOLR1 (0.57) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL9564229 | 0.91 | FOLR1 (0.46) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL8982495 | 0.86 | FOLR1 (0.53) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL8982600 | 0.86 | FOLR1 (0.53) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL8982494 | 0.86 | FOLR1 (0.53) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL9039220 | 0.85 | DHFR (0.57) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL9039215 | 0.85 | DHFR (0.57) | FOLR1SLC46A1SLC19A1GARTDHFR | |
| SCHEMBL9439673 | 0.84 | FOLR1 (0.75) | FOLR1SLC46A1SLC19A1GARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354754-A | Antitumor and -carcinogenic agents; treating human epidermoid carcinoma KB | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-11 | — | — | US | disclosed |
| EP-0418924-A2 | Pyrrolopyrimidines, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-03-27 | — | — | EP | disclosed |