Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685614 | 0.83 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL10643598 | 0.81 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL13967844 | 0.81 | TDP1 (0.48) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL7276080 | 0.81 | TDP1 (0.48) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL29104740 | 0.80 | TDP1 (0.52) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL31469524 | 0.78 | TDP1 (0.50) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL440977 | 0.78 | TDP1 (0.50) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL10010403 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| Acetic Acid SCHEMBL17267836 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10TDP1TSHR | |
| SCHEMBL7399669 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |