Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399674 | 1.00 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10GLO1CPB2 | |
| SCHEMBL10643598 | 0.83 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10GLO1TSHR | |
| SCHEMBL1657391 | 0.82 | ALDH1A1 (0.36) | ALDH1A1LMNAHSD17B10TSHRMGAM | |
| SCHEMBL6685614 | 0.81 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10GLO1TSHR | |
| SCHEMBL1268708 | 0.81 | ALDH1A1 (0.41) | ALDH1A1LMNAHSD17B10GLO1CPB2 | |
| SCHEMBL22086836 | 0.80 | TSHR (0.50) | ALDH1A1LMNAHSD17B10TSHRALOX15 | |
| Acetic Acid SCHEMBL17267836 | 0.80 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10GLO1TSHR | |
| SCHEMBL18675838 | 0.79 | ALDH1A1 (0.40) | ALDH1A1LMNAHSD17B10GLO1CPB2 | |
| SCHEMBL9439802 | 0.78 | ALDH1A1 (0.52) | ALDH1A1LMNAHSD17B10GLO1TSHR | |
| SCHEMBL14595014 | 0.77 | TSHR (0.39) | LMNATSHRALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |