Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 12/20 | 0.45 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267968 | 1.00 | KDM4E (0.46) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9443453 | 1.00 | KDM4E (0.46) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9443496 | 0.85 | KCNE1 (0.46) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9249195 | 0.84 | KDM4E (0.43) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9249188 | 0.84 | KDM4E (0.43) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9030980 | 0.84 | KDM4E (0.46) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9443533 | 0.83 | ABCB1 (0.43) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9443526 | 0.82 | ABCB1 (0.42) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9735474 | 0.81 | ABCB1 (0.41) | KDM4EABCB1KCNE1KCNQ1MEN1 | |
| SCHEMBL9443538 | 0.80 | KCNE1 (0.45) | KDM4EABCB1ABCC9KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232944-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0422450-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-04-17 | — | — | EP | disclosed |